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Thrombosis Prevention and ManagementThrombosis Prevention and Management in the Older Adult
A Case-Based Educational Program

Prior to working on the case studies, the following journal articles are suggested as readings. These articles will provide you with the foundation to understand the pathophysiology of commonly encountered thromboembolic disorders and their pharmacological treatments. To open the PDF files you will need Adobe Acrobat Reader that can be downloaded at no cost.

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Suggested Readings

The Clinical Diagnosis of Deep Venous Thrombosis: Integrating Incidence, Risk Factors, and Symptoms and Signs
  Susan R. Kahn
Arch Intern Med 1998; 158: 2315-23.[Full Text] [PDF]

Thrombus Formation on Atherosclerotic Plaques: Pathogenesis and Clinical Consequences
  Ursula Rauch, Julio I. Osende, Valentin Fuster, et al.
Ann Intern Med 2001; 134:224-38. [Full Text] [PDF]

Relative Impact of Risk Factors for Deep Vein Thrombosis and Pulmonary Embolism: A Population-Based Study
  John A. Heit, Michael O"Fallon, Tanya M. Petterson, et al.
Arch Intern Med 2002; 162:1245-8. [Full Text] [PDF]

Strategies to Improve Compensation for Pharmaceutical Care Services
  Marialice S. Bennett, Dawn Blank, Janice Bopp, et al.
J Am Pharm Assoc 2000; 40:747-55. [PDF]

Readings from the American College of Chest Physicians Sixth Consensus Conference on Antithrombotic Therapy
  [Chest, volume 119, number 1 (supplement), January 2001]

The following reading materials are from the American College of Chest Physicians (ACCP) consensus guidelines that are the premiere authoritative source for current treatment strategies.
These readings can be downloaded from the ACCP web site (http://www.chestjournal.org/content/vol119/1_suppl). You can purchase a hardcopy of the entire guideline directly from ACCP Consensus Conference Statement and Practice Guidelines which may be ordered from ACCP Member Services Division at (847) 498-1400 or (800) 343-2227 ; Fax : (847) 498-5460. The cost of the printed 370 page guideline is $18.00.

The Sixth (2000) ACCP Guidelines for Antithrombotic Therapy for Prevention and Treatment of Thrombosis
  Jack Hirsh, James E. Dalen, and Gordon Guyatt
Chest 119: 1S-2S. [Full Text] [PDF]

Grades of Recommendation for Antithrombotic Agents
  Gordon Guyatt, Holger Schunëmann, Deborah Cook, Roman Jaeschke, Stephen Pauker, and Heiner Bucher
Chest 119: 3S-7S. [Full Text] [PDF]

Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range
  Jack Hirsh, James E. Dalen, David R. Anderson, Leon Poller, Henry Bussey, Jack Ansell, and Daniel Deykin
Chest 119: 8S-21S. [Full Text] [PDF]

Managing Oral Anticoagulant Therapy
  Jack Ansell, Jack Hirsh, James Dalen, Henry Bussey, David Anderson, Leon Poller, Alan Jacobson, Daniel Deykin, and David Matchar
Chest 119: 22S-38S. [Full Text] [PDF]

Platelet-Active Drugs : The Relationships Among Dose, Effectiveness, and Side Effects
  Carlo Patrono, Barry Coller, James E. Dalen, Garret A. FitzGerald, Valentin Fuster, Michael Gent, Jack Hirsh, and Gerald Roth
Chest 119: 39S-63S. [Full Text] [PDF]

Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety
  Jack Hirsh, Theodore E. Warkentin, Stephen G. Shaughnessy, Sonia S. Anand, Jonathan L. Halperin, Robert Raschke, Christopher Granger, E. Magnus Ohman, and James E. Dalen
Chest 119: 64S-94S. [Full Text] [PDF]

New Anticoagulant Drugs
  Jeffrey I. Weitz and Jack Hirsh
Chest 119: 95S-107S. [Full Text] [PDF]

Hemorrhagic Complications of Anticoagulant Treatment
  Mark N. Levine, Gary Raskob, Seth Landefeld, and Clive Kearon
Chest 119: 108S-121S. [Full Text] [PDF]

Prevention of Venous Thromboembolism
  William H. Geerts, John A. Heit, G. Patrick Clagett, Graham F. Pineo, Clifford W. Colwell, Frederick A. Anderson, Jr., and H. Brownell Wheeler
Chest 119: 132S-175S. [Full Text] [PDF]

Antithrombotic Therapy for Venous Thromboembolic Disease
  Thomas M. Hyers, Giancarlo Agnelli, Russell D. Hull, Timothy A. Morris, Michel Samama, Victor Tapson, and John G. Weg
Chest 119: 176S-193S. [Full Text] [PDF]

Antithrombotic Therapy in Atrial Fibrillation
  Gregory W. Albers, James E. Dalen, Andreas Laupacis, Warren J. Manning, Palle Petersen, and Daniel E. Singer
Chest 119: 194S-206S. [Full Text] [PDF]

Antithrombotic Therapy in Valvular Heart Disease
  Deeb N. Salem, Denise Hartnett Daudelin, Herbert J. Levine, Stephen G. Pauker, Mark H. Eckman, and Joshua Riff
Chest 119: 207S-219S. [Full Text] [PDF]

Antithrombotic Therapy in Patients With Mechanical and Biological Prosthetic Heart Valves
  Paul D. Stein, Joseph S. Alpert, Henry I. Bussey, James E. Dalen, and Alexander G.G. Turpie
Chest 119: 220S-227S. [Full Text] [PDF]

Antithrombotic Agents in Coronary Artery Disease
  John A. Cairns, Pierre Théroux, H. Daniel Lewis, Jr., Michael Ezekowitz, and Thomas W. Meade
Chest 119: 228S-252S. [Full Text] [PDF]

Antithrombotic Therapy in Peripheral Arterial Occlusive Disease
  Mark R. Jackson and G. Patrick Clagett
Chest 119: 283S-299S. [Full Text] [PDF]

Antithrombotic and Thrombolytic Therapy for Ischemic Stroke
  Gregory W. Albers, Pierre Amarenco, J. Donald Easton, Ralph L. Sacco, and Philip Teal
Chest 119: 300S-320S. [Full Text] [PDF]

 

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